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Hepatitis A (HAV) |
Hepatitis B (HBV) |
Hepatitis C (HCV) |
Hepatitis D (HDV) |
Hepatitis E (HEV) |
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What is it? |
HAV is a virus that causes inflammation of the liver. It does not lead to chronic disease. |
HBV is a virus That causes inflammation of the liver. It can cause liver cell damage, leading to cirrhosis and cancer. |
HCV is a virus that causes inflammation of the liver. It can cause liver cell damage, leading to cirrhosis and cancer. |
HDV is a virus that causes inflammation of the liver. It only infects those persons with HBV. |
HEV is a virus that causes inflammation of the liver. It is rare in the U.S. There is no chronic state. |
Incubation Period |
2 to 7 weeks. Average 4 weeks. |
6 to 23 weeks. Average 17 weeks. |
2 to 25 weeks. Average 7 to 9 wks. |
2 to 8 weeks. | 2 to 9 weeks. Average 40 days. |
How is it Spread? |
Transmitted by fecal/oral route, through close person to person contact or ingestion of contaminated food and water. | Contact with infected blood, seminal fluid, vaginal secretions, contaminated needles, including tattoo and body-piercing tools. Infected mother to newborn. Human bite. Sexual contact. | Contact with infected blood, contaminated IV needles, razors, and tattoo or body- piercing tools. Infected mother to newborn. NOT easily spread through sex. | Contact with infected blood, contaminated needles. Sexual contact with HDV infected person. | Transmitted through fecal/oral route. Outbreaks associated with contaminated water supply in other countries. |
Symptoms |
May have none. Others may have light stools, dark urine, fatigue, fever, nausea, vomiting, abdominal pain, and jaundice. | May have none. Some persons have mild flu-like symptoms, dark urine, light stools, jaundice, fatigue and fever. | Same as HBV | Same as HBV | Same HBV |
Treatment of Chronic Disease |
Not applicable. | Interferon and Lamivudine with varying success. | Interferon and combination therapies with varying success. | Interferon with varying success. | Not Applicable. |
Vaccine |
Two doses of vaccine to anyone over 2 yrs of age or older. | Three doses may be given to persons of any age. | None | HBV vaccine prevents HDV infection. | None |
Who is at Risk? |
Household or sexual contact with an infected person or living in an area with HAV outbreak. Travelers to developing countries, persons engaging in anal/oral sex and injection drug users. | Infants born to infected mother, having sex with an infected person or multiple partners, injection drug users, emergency responders, healthcare workers, persons engaging in anal/oral sex, and hemodialysis patients. | Blood transfusion recipients before 1992, healthcare workers, injection drug users, hemodialysis patients, infants born to infected mother, multiple sex partners. | Injection drug users, persons engaging in anal/oral sex and those having sex with an HDV infected person. | Travelers to developing countries, especially pregnant women. |
Prevention |
Immune Globulin within 2 wks of exposure. Vaccination. Washing hands with soap and water after going to the toilet. Use household bleach (10 parts water to 1 part bleach) to clean surfaces contaminated with feces, such as changing tables. Safe sex. | Immune Globulin within 2 wks of exposure. Vaccination provides protection for 18 years. Clean up infected blood with household bleach and wear protective gloves. Do not share razors, toothbrushes, or needles. Safe sex. | Clean up spilled blood with household bleach. Wear gloves when touching blood. Do not share razors, toothbrushes, or needles with anyone. Safe sex. | Hepatitis B vaccine to prevent HBV infection. Safe sex. | Avoid drinking or using potentially contaminated water. |
Updated: 2-4-2002
Source: Hepatitis Foundation International
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